Abstract
Rats were administered either amitriptyline (20 mg kg-1, i.p.) or mianserin (10 mg kg-1, i.p.) for 21 consecutive days and the alpha- and beta-adrenoceptor characteristics of cardiac ventricles, cerebral cortex and hippocampus examined by ligand-binding procedure. Chronic administration of amitriptyline significantly reduced the maximum density of beta-receptors in the cerebral cortex without significantly altering cardiac alpha- or beta-receptors; mianserin treatment had no significant effect on any of the receptors studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amitriptyline / pharmacology*
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Animals
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Brain / drug effects*
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Brain / metabolism
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Cerebral Cortex / drug effects
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Dibenzazepines / pharmacology*
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Heart / drug effects*
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Heart Ventricles / drug effects
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Hippocampus / drug effects
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Male
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Mianserin / pharmacology*
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Myocardium / metabolism
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Rats
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Rats, Inbred Strains
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Receptors, Adrenergic, alpha / drug effects*
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Receptors, Adrenergic, beta / drug effects*
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Time Factors
Substances
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Dibenzazepines
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Receptors, Adrenergic, alpha
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Receptors, Adrenergic, beta
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Amitriptyline
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Mianserin