Characterizing Surface-Immobilized DNA Structures and Devices Using a Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D)

Katherine E Dunn; Martin A Trefzer; Steven Johnson; Andy M Tyrrell

doi:10.1007/978-1-4939-8582-1_7

Characterizing Surface-Immobilized DNA Structures and Devices Using a Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D)

Methods Mol Biol. 2018:1811:101-114. doi: 10.1007/978-1-4939-8582-1_7.

Authors

Katherine E Dunn^{1

2}, Martin A Trefzer³, Steven Johnson³, Andy M Tyrrell³

Affiliations

¹ Department of Electronic Engineering, University of York, Heslington, York, UK. k.dunn@ed.ac.uk.
² Institute for Bioengineering, School of Engineering, University of Edinburgh, Edinburgh, Scotland, UK. k.dunn@ed.ac.uk.
³ Department of Electronic Engineering, University of York, Heslington, York, UK.

PMID: 29926448
DOI: 10.1007/978-1-4939-8582-1_7

Abstract

A quartz crystal microbalance with dissipation monitoring can be used to study the mass and structure of surface-immobilized layers of molecules, in real time. Here we describe the use of the technique to study DNA structures and devices.

Keywords: DNA molecular machines; DNA nanostructures; QCM-D; Surface-immobilization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques
Immobilized Nucleic Acids / chemistry*
Quartz
Quartz Crystal Microbalance Techniques / instrumentation*
Surface Properties

Substances

Immobilized Nucleic Acids
Quartz