Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals

Bull Exp Biol Med. 2018 Jun;165(2):239-242. doi: 10.1007/s10517-018-4138-2. Epub 2018 Jun 19.

Abstract

The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant system, due to which the destructive effects of ROS could be partially neutralized during the vaccinal process.

Keywords: antioxidant status; immunization; lipid peroxidation; oxidative stress.

MeSH terms

  • Animal Structures / drug effects*
  • Animal Structures / metabolism
  • Animals
  • Animals, Laboratory
  • Antioxidants / metabolism*
  • Brucella Vaccine / chemistry
  • Brucella Vaccine / pharmacology*
  • Brucella abortus / chemistry*
  • Brucella abortus / immunology
  • Brucella abortus / pathogenicity
  • Female
  • Guinea Pigs
  • L Forms / physiology
  • Lipid Peroxidation / drug effects*
  • Liver / drug effects
  • Liver / metabolism
  • Liver / pathology
  • Male
  • Oxidative Stress / drug effects
  • Spheroplasts / physiology
  • Temperature
  • Vaccines, Attenuated / chemistry
  • Vaccines, Attenuated / pharmacology*

Substances

  • Antioxidants
  • Brucella Vaccine
  • Vaccines, Attenuated