Abstract
The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant system, due to which the destructive effects of ROS could be partially neutralized during the vaccinal process.
Keywords:
antioxidant status; immunization; lipid peroxidation; oxidative stress.
MeSH terms
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Animal Structures / drug effects*
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Animal Structures / metabolism
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Animals
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Animals, Laboratory
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Antioxidants / metabolism*
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Brucella Vaccine / chemistry
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Brucella Vaccine / pharmacology*
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Brucella abortus / chemistry*
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Brucella abortus / immunology
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Brucella abortus / pathogenicity
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Female
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Guinea Pigs
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L Forms / physiology
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Lipid Peroxidation / drug effects*
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Liver / drug effects
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Liver / metabolism
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Liver / pathology
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Male
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Oxidative Stress / drug effects
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Spheroplasts / physiology
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Temperature
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Vaccines, Attenuated / chemistry
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Vaccines, Attenuated / pharmacology*
Substances
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Antioxidants
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Brucella Vaccine
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Vaccines, Attenuated