Association of vitamin D receptor BsmI, TaqI, FokI, and ApaI polymorphisms with susceptibility of chronic periodontitis: A systematic review and meta-analysis based on 38 case -control studies

Fatemeh Mashhadiabbas; Hossein Neamatzadeh; Rezvan Nasiri; Elnaz Foroughi; Soudabeh Farahnak; Parisa Piroozmand; Mahta Mazaheri; Masoud Zare-Shehneh

Association of vitamin D receptor BsmI, TaqI, FokI, and ApaI polymorphisms with susceptibility of chronic periodontitis: A systematic review and meta-analysis based on 38 case -control studies

Dent Res J (Isfahan). 2018 May-Jun;15(3):155-165.

Authors

Fatemeh Mashhadiabbas¹, Hossein Neamatzadeh^{2

3}, Rezvan Nasiri⁴, Elnaz Foroughi⁵, Soudabeh Farahnak⁶, Parisa Piroozmand⁷, Mahta Mazaheri^{2

3}, Masoud Zare-Shehneh²

Affiliations

¹ Department of Oral and Maxillofacial Pathology, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
³ Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁴ Departments of Restorative and Esthetic, Arak University of Medical Science, Arak, Iran.
⁵ Pediatric Dentistry, Arak University of Medical Science, Arak, Iran.
⁶ Endodontics, Dental School, Arak University of Medical Science, Arak, Iran.
⁷ Department of Oral and Maxillofacial Medicine, Dental School, Ardabil University of Medical Science, Ardabil, Iran.

PMID: 29922333
PMCID: PMC5958531

Abstract

Background: There has been increasing interest in the study of the association between Vitamin D receptor (VDR) gene polymorphisms and risk of chronic periodontitis. However, the results remain inconclusive. To better understand the roles of VDR polymorphisms (BsmI, TaqI, FokI, and ApaI) in chronic periodontitis susceptibility, we conducted this systematic review and meta-analysis.

Materials and methods: The PubMed, Google Scholar, and Web of Science database were systemically searched to determine all the eligible studies about VDR polymorphisms and risk of chronic periodontitis up to April 2017. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between VDR polymorphisms and chronic periodontitis risk. All the statistical analyses were performed by Comprehensive Meta-Analysis. All P values were two-tailed with a significant level at 0.05.

Results: Finally, a total of 38 case-control studies in 19 publications were identified which met our inclusion criteria. There are ten studies with 866 chronic periodontitis cases and 786 controls for BsmI, 16 studies with 1570 chronic periodontitis cases and 1676 controls for TaqI, five studies with 374 chronic periodontitis cases and 382 controls for FokI, and seven studies with 632 chronic periodontitis cases and 604 controls for ApaI. Overall, no significant association was observed between VDR gene BsmI, TaqI, FokI, and ApaI polymorphisms and risk of chronic periodontitis in any genetic model. Subgroup analysis stratified by ethnicity suggested a significant association between BsmI polymorphism and chronic periodontitis risk in the Caucasian subgroup under allele model (A vs. G: OR = 1.747, 95% CI = 1.099-2.778, P = 0.018). Further, no significant associations were observed when stratified by Hardy-Weinberg equilibrium status for BsmI, TaqI, and ApaI.

Conclusion: Our results suggest that BsmI, TaqI, FokI, and ApaI polymorphisms in the VDR gene might not be associated with risk of chronic periodontitis in overall population.

Keywords: Chronic periodontitis; Vitamin D receptor; meta-analysis; polymorphism.

Publication types

Review