The protective capacity of high payload FMDV A22 IRQ vaccine in sheep against direct-contact challenge with a heterologous, contemporary FMDV A strain from South East Asia

PLoS One. 2018 Jun 18;13(6):e0195302. doi: 10.1371/journal.pone.0195302. eCollection 2018.

Abstract

Foot-and-mouth disease (FMD) is an acute, highly contagious viral disease of domestic and wild cloven-hoofed animals, caused by FMD virus (FMDV). An FMD outbreak can cause major production losses and have significant implications for trade. Vaccination can assist in controlling the disease, and emergency vaccination using high antigen payload vaccines (>6 PD50/dose) is considered an important control approach in the event of an outbreak. In recent years there has been a divergence of serotype A viruses in South East Asia (SEA) into several distinct genetic and antigenic clusters. Numerous variants were found to poorly match serotype A vaccines commonly included in international antigen banks. This study examined the ability of single vaccination with high-potency monovalent A22 IRQ vaccine to protect sheep following challenge with the A/VIT/15/2012 strain, just four days following vaccination. The vaccine proved effective at limiting clinical disease but did not prevent infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Foot-and-Mouth Disease Virus / immunology*
  • Foot-and-Mouth Disease* / immunology
  • Foot-and-Mouth Disease* / prevention & control
  • Sheep* / immunology
  • Sheep* / virology
  • Viral Vaccines* / immunology
  • Viral Vaccines* / pharmacology

Substances

  • Viral Vaccines

Grants and funding

Funding was provided in part by producer levies held by Animal Health Australia on behalf of Cattle Council of Australia, Australian Dairy Farmers, Australian Lot Feeders Association, Wool Producers Australia, Sheepmeat Council of Australia, Australian Pork Limited and the Goat Industry Council of Australia. The AHA industry funds are matched through the Meat and Livestock Australia Donor Company by the Australian Government under MLA Project P.PSH 0652. The work was supported by in-kind contributions by the CFIA-NCAD in the form of facilities and support staff.