Mass spectrometry in pathology - Vision for a future workflow

Jörg Kriegsmann; Rita Casadonte; Katharina Kriegsmann; Rémi Longuespée; Mark Kriegsmann

doi:10.1016/j.prp.2018.05.009

Mass spectrometry in pathology - Vision for a future workflow

Pathol Res Pract. 2018 Aug;214(8):1057-1063. doi: 10.1016/j.prp.2018.05.009. Epub 2018 May 17.

Authors

Jörg Kriegsmann¹, Rita Casadonte², Katharina Kriegsmann³, Rémi Longuespée⁴, Mark Kriegsmann⁵

Affiliations

¹ MVZ for Histology, Cytology and Molecular Diagnostics Trier, Trier, Germany; Proteopath GmbH, Trier, Germany.
² Proteopath GmbH, Trier, Germany.
³ Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
⁴ Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
⁵ Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: mark.kriegsmann@med.uni-heidelberg.de.

PMID: 29910062
DOI: 10.1016/j.prp.2018.05.009

Abstract

Mass spectrometric (MS) techniques are applied in various areas of medical diagnostics. For the detection of microbiological germs and genetic mutations, MS is a method used in routine. Since MS also allows the analysis of proteins and peptides, it seems an ideal candidate to supplement histopatholological diagnostics. Matrix-assisted laser desorption/ionization time-of-flight Imaging MS links molecular analysis of numerous analytes with morphological information about their spatial distribution in cells or tissues. Herein, we review principle MS techniques as well as potential applications in pathology and discuss our vision for a future workflow.

Keywords: MALDI Imaging; Mass Spectrometry; Molecular Pathology; Pathology Workflow.

Publication types

Review

MeSH terms

Humans
Mass Spectrometry / methods*
Mass Spectrometry / trends*
Pathology, Clinical / methods*
Pathology, Clinical / trends*
Workflow