Dynamic interactions between GABAergic and astrocytic networks

Annamaria Lia; Micaela Zonta; Linda Maria Requie; Giorgio Carmignoto

doi:10.1016/j.neulet.2018.06.026

Dynamic interactions between GABAergic and astrocytic networks

Neurosci Lett. 2019 Jan 10:689:14-20. doi: 10.1016/j.neulet.2018.06.026. Epub 2018 Jun 15.

Authors

Annamaria Lia¹, Micaela Zonta², Linda Maria Requie¹, Giorgio Carmignoto¹

Affiliations

¹ University of Padua, Department of Biomedical Sciences, Padua, Italy; CNR, Neuroscience Institute, Padua, Italy.
² University of Padua, Department of Biomedical Sciences, Padua, Italy; CNR, Neuroscience Institute, Padua, Italy. Electronic address: micaela.zonta@cnr.it.

PMID: 29908949
DOI: 10.1016/j.neulet.2018.06.026

Abstract

Brain network activity derives from the concerted action of different cell populations. Together with interneurons, astrocytes play fundamental roles in shaping the inhibition in brain circuitries and modulating neuronal transmission. In this review, we summarize past and recent findings that reveal in neural networks the importance of the interaction between GABAergic signaling and astrocytes and discuss its physiological and pathological relevance.

Keywords: Astrocytes; Calcium signaling; GABA; Interneurons; Synaptic transmission.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Astrocytes / cytology
Astrocytes / metabolism*
Astrocytes / pathology
Brain Diseases / metabolism
Brain Diseases / pathology
Calcium Signaling
GABAergic Neurons / cytology
GABAergic Neurons / metabolism*
GABAergic Neurons / pathology
Humans
Interneurons / cytology
Interneurons / metabolism
Interneurons / pathology
Synaptic Transmission / physiology*