Use of iontophoresis for the treatment of cancer

James D Byrne; Jen Jen Yeh; Joseph M DeSimone

doi:10.1016/j.jconrel.2018.06.020

Use of iontophoresis for the treatment of cancer

J Control Release. 2018 Aug 28:284:144-151. doi: 10.1016/j.jconrel.2018.06.020. Epub 2018 Jun 15.

Authors

James D Byrne¹, Jen Jen Yeh², Joseph M DeSimone³

Affiliations

¹ Harvard Radiation Oncology Program, Boston, MA 02114, USA. Electronic address: jdbyrne@partners.org.
² Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Surgical Oncology, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
³ Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.

PMID: 29908892
DOI: 10.1016/j.jconrel.2018.06.020

Abstract

Despite major advancements in cancer treatments, there are still many limitations to therapy including off-target effects, drug resistance, and control of cancer-related symptoms. There are opportunities for local drug delivery devices to intervene at various stages of cancer to provide curative and palliative benefit. Iontophoretic devices that deliver drugs locally to a region of interest have been adapted for the treatment of cancer. These devices have shown promise in pre-clinical and clinical studies for retinoblastoma, skin, bladder, and pancreatic cancers. Herein, we review iontophoretic devices used in the management of cancer.

Keywords: Cancer; Chemotherapies; Devices; Drug delivery; Iontophoresis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / therapeutic use
Drug Delivery Systems / instrumentation*
Drug Delivery Systems / methods
Equipment Design
Humans
Iontophoresis / instrumentation*
Iontophoresis / methods
Neoplasms / drug therapy*
Translational Research, Biomedical

Substances

Antineoplastic Agents

Grants and funding

P30 CA016086/CA/NCI NIH HHS/United States