Back to homeostasis: Negative regulation of NF-κB immune signaling in insects

Dev Comp Immunol. 2018 Oct:87:216-223. doi: 10.1016/j.dci.2018.06.007. Epub 2018 Jun 14.

Abstract

Maintenance of homeostasis requires prompt activation and down-regulation of immune signaling pathways. This review attempts to summarize our current knowledge regarding the negative regulation of two NF-κB signaling pathways in insects, Toll and IMD pathway, which are mostly essential for host defense against bacteria and fungus. Various types of negative regulators and their mechanisms are discussed here with the emphasis on the prominent roles of ubiquitination. The counterbalance between these two pathways, the crosstalk with other physiological pathways, and the difference in their repertoires of negative regulators are also discussed.

Keywords: IMD pathway; Insect; Negative regulation; Toll pathway; Ubiquitination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / immunology
  • Disease Resistance / immunology
  • Fungi / immunology
  • Homeostasis / immunology*
  • Host-Pathogen Interactions / immunology
  • Insect Proteins / immunology
  • Insect Proteins / metabolism
  • Insecta / immunology*
  • Insecta / metabolism
  • Insecta / microbiology
  • NF-kappa B / immunology*
  • NF-kappa B / metabolism
  • Signal Transduction / immunology*
  • Toll-Like Receptors / immunology
  • Toll-Like Receptors / metabolism

Substances

  • Insect Proteins
  • NF-kappa B
  • Toll-Like Receptors