Objective: To investigate the disorder of lipid metabolism in type 2diabetic patients. To assessed the association of cholesterol and apolipoprotein with derangement of glucose metabolism.
Methods: The levels of TC, TG, HDL-C, LDL-C, Apo A1, Apo A2, Apo AB48, Apo B100 and Apo E were all measured in 60 type 2 diabetic patients and 60 healthy controls. The differences of these clinical indicators in the two groups have been compared. Correlation analysis, multiple regression analysis have been applied in this paper.
Results: The levels of TC, TG, LDL-C were significantly higher( P < 0. 01) and the level of HDL-C was significantly lower( P < 0. 01) in patients with type 2 diabetes which indicating a lipid metabolic abnormalities. The levels of Apo A2, Apo B100, Apo E were significantly higher in type 2 diabetic patients than those in control group. Multiple regression analysis showed that Apo B100, Apo B48, LDL-C, TG were the main factors of FBG level. It was showed that apolipoproteins, especially Apo B, isassociated with glucose metabolism disorder.
Conclusion: T2 DM patients are obviously associated with abnormal lipid metabolism, and the apolipoproteins may play an important role in derangement of glucose metabolism.
Keywords: apolipoprotein; lipid metabolism disorder; type 2 diabetes mellitus.