[A new fatty acid methyl ester from Fissistigma oldhamii inhibiting proliferation of synoviocytes]

Xue-Ming Zhou; Bin Zhang; Yu-Qin Zhang; Guang-Ying Chen; Wei Xu; Jin Cai; Shan Liao

doi:10.19540/j.cnki.cjcmm.20180125.006

[A new fatty acid methyl ester from Fissistigma oldhamii inhibiting proliferation of synoviocytes]

Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1754-1757. doi: 10.19540/j.cnki.cjcmm.20180125.006.

[Article in Chinese]

Authors

Xue-Ming Zhou¹, Bin Zhang¹, Yu-Qin Zhang², Guang-Ying Chen¹, Wei Xu², Jin Cai¹, Shan Liao¹

Affiliations

¹ Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
² College of Pharmacy, Fujian University of Traditional Chinese Medicine College of Pharmacy, Fuzhoun 350122, China.

PMID: 29902881
DOI: 10.19540/j.cnki.cjcmm.20180125.006

Abstract

A new fatty acid methyl ester (1) was isolated from an EtOH extract of Fissistigma oldhamii. It structures was elucidated by a combination of HR-ESI-MS, 1D NMR, 2D NMR, UV, and IR spectroscopic data. The inhibitory effect of compound 1 on the proliferation of primary synovial cells was evaluated. As a result, it showed inhibitory effect on the proliferation of synoviocytes, with IC₅₀ value of 38.6 μmol·L⁻¹.

Keywords: Annonaceae; Fissistigma oldhamii; fatty acid methyl ester; synoviocytes.

MeSH terms

Annonaceae*
Cell Proliferation
Esters
Fatty Acids
Magnetic Resonance Spectroscopy
Molecular Structure
Synoviocytes*

Substances

Esters
Fatty Acids