Data set on G4 DNA interactions with human proteins

M Vlasenok; O Levchenko; D Basmanov; D Klinov; A Varizhuk; G Pozmogova

doi:10.1016/j.dib.2018.02.081

Data set on G4 DNA interactions with human proteins

Data Brief. 2018 Mar 9:18:348-359. doi: 10.1016/j.dib.2018.02.081. eCollection 2018 Jun.

Authors

M Vlasenok¹, O Levchenko¹, D Basmanov¹, D Klinov¹, A Varizhuk¹, G Pozmogova¹

Affiliation

¹ Research and Clinical Center for Physical Chemical Medicine, 119435 Moscow, Russia.

Abstract

Guanine-rich DNA/RNA fragments can fold into G-quadruplexes (G4s) - non-canonical four-strand secondary structures. The article contains data on quadruplex interaction with human proteins. Binding of three topologically different G4 structures to more than 9000 human proteins was analyzed. Physicochemical methods were used to verify the results.The dataset was generated to identify the protein targets for DNA quadruplex structures for the purpose of better understanding the role of the structures in gene expression regulation. Presented data include functional interpretation of obtained gene lists, visualized with Cytoscape.