Abstract
In vivo benzodiazepine receptor binding has generally been studied by "ex vivo" techniques. In this investigation, we identify the conditions where [3H]-Ro 15-1788 labels benzodiazepine receptors by true "in vivo" binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homogenization or washing. [3H]-Flunitrazepam and [3H]-clonazepam did not exhibit useful in vivo receptor binding.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Autoradiography
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Benzodiazepinones / metabolism*
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Brain / metabolism
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Clonazepam / metabolism
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Flumazenil
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Flunitrazepam / metabolism
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In Vitro Techniques
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Male
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Mice
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Mice, Inbred ICR
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Receptors, GABA-A / metabolism*
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Time Factors
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Tritium
Substances
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Benzodiazepinones
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Receptors, GABA-A
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Tritium
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Flumazenil
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Clonazepam
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Flunitrazepam