Antifungal Proteins with Antiproliferative Activity on Cancer Cells and HIV-1 Enzyme Inhibitory Activity from Medicinal Plants and Medicinal Fungi

Jack Ho Wong; Tzi Bun Ng; Hexiang Wang; Randy Chi Fai Cheung; Charlene Cheuk Wing Ng; Xiuyun Ye; Jie Yang; Fang Liu; Chen Ling; Ki Chan; Xiujuan Ye; Wai Yee Chan

doi:10.2174/1389203719666180613085704

Antifungal Proteins with Antiproliferative Activity on Cancer Cells and HIV-1 Enzyme Inhibitory Activity from Medicinal Plants and Medicinal Fungi

Curr Protein Pept Sci. 2019;20(3):265-276. doi: 10.2174/1389203719666180613085704.

Authors

Jack Ho Wong¹, Tzi Bun Ng¹, Hexiang Wang², Randy Chi Fai Cheung¹, Charlene Cheuk Wing Ng¹, Xiuyun Ye³, Jie Yang³, Fang Liu⁴, Chen Ling⁵, Ki Chan⁶, Xiujuan Ye⁷, Wai Yee Chan¹

Affiliations

¹ School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
² State Key Laboratory for Agrobiotechnology and Department of Microbiology, China Agricultural University, Beijing, China.
³ National Engineering Laboratory for High-Efficiency Enzyme Expression and College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, China.
⁴ Department of Microbiology, Nankai University, Tianjin, China.
⁵ Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32611, FL, United States.
⁶ Biomedical and Tissue Engineering Research Group, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong, China.
⁷ Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, and Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.

PMID: 29895244
DOI: 10.2174/1389203719666180613085704

Abstract

A variety of fungi, plants, and their different tissues are used in Traditional Chinese Medicine to improve health, and some of them are recommended for dietary therapy. Many of these plants and fungi contain antifungal proteins and peptides which suppress spore germination and hyphal growth in phytopathogenic fungi. The aim of this article is to review antifungal proteins produced by medicinal plants and fungi used in Chinese medicine which also possess anticancer and human immunodeficiency virus-1 (HIV-1) enzyme inhibitory activities.

Keywords: Antifungal proteins; anti-HIV-1 enzymes; anticancer; medicinal fungi; medicinal plants..

Publication types

Review

MeSH terms

Animals
Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology*
Antifungal Agents* / chemistry
Antifungal Agents* / pharmacology
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Fungal Proteins* / chemistry
Fungal Proteins* / pharmacology
Humans
Medicine, Chinese Traditional
Plant Proteins* / chemistry
Plant Proteins* / pharmacology
Plants, Medicinal / chemistry*

Substances

Anti-HIV Agents
Antifungal Agents
Antineoplastic Agents
Fungal Proteins
Plant Proteins