Characterization data for T cell-specific Blimp-1 transgenic C57BL/6 mice

Aline Yen Ling Wang; Charles Yuen Yung Loh; Shyi-Jou Chen; Huang-Kai Kao; Cheng-Hung Lin; Sheng-Hao Chuang; Chin-Ming Lee; Huey-Kang Sytwu; Fu-Chan Wei

doi:10.1016/j.dib.2018.04.132

Characterization data for T cell-specific Blimp-1 transgenic C57BL/6 mice

Data Brief. 2018 May 8:19:117-127. doi: 10.1016/j.dib.2018.04.132. eCollection 2018 Aug.

Authors

Aline Yen Ling Wang¹, Charles Yuen Yung Loh^{2

3}, Shyi-Jou Chen^{4

5}, Huang-Kai Kao^{6

7}, Cheng-Hung Lin^{1

6}, Sheng-Hao Chuang¹, Chin-Ming Lee⁸, Huey-Kang Sytwu⁹, Fu-Chan Wei^{1

6

7}

Affiliations

¹ Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
² Division of Surgery and Interventional Science, University College London, London, United Kingdom.
³ St Andrew's Center for Burns and Plastic Surgery, Chelmsford, United Kingdom.
⁴ Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
⁵ Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan.
⁶ Department of Plastic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁷ College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁸ Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁹ Department of Microbiology and Immunology, Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Abstract

This article is the first to provide characterization data regarding naive C57BL/6 transgenic mice with overexpression of B lymphocyte-induced maturation protein 1 (Blimp-1) under a T cell-specific pLCK promoter. The data presented are related to phenotype, Blimp-1 overexpression levels, T cell development and T cell proliferation for Blimp-1 transgenic mice. For further Blimp-1 overexpressed T cell findings regarding skin allotransplantation, please refer to the research article "Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1" (Wang et al., 2018) [1].

Keywords: Blimp-1; T cell; Transgenic mice.