Synergistic antibacterial activity between penicillenols and antibiotics against methicillin-resistant Staphylococcus aureus

Shuihong Li; Qianqian Mou; Xinya Xu; Shuhua Qi; Polly H M Leung

doi:10.1098/rsos.172466

Synergistic antibacterial activity between penicillenols and antibiotics against methicillin-resistant Staphylococcus aureus

R Soc Open Sci. 2018 May 30;5(5):172466. doi: 10.1098/rsos.172466. eCollection 2018 May.

Authors

Shuihong Li¹, Qianqian Mou², Xinya Xu³, Shuhua Qi³, Polly H M Leung²

Affiliations

¹ Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, People's Republic of China.
² Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong 999077, People's Republic of China.
³ Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, People's Republic of China.

Abstract

Penicillenol A2 (isolated from deep-sea fungus Penicillium biourgeianum DFFSCS023) has good antibacterial activity against methicillin-sensitive Staphylococcus aureus and in combination with beta-lactam antibiotics it could significantly decrease methicillin-resistant Staphylococcus aureus (MRSA) survival, which provides a novel treatment consideration for MRSA-caused infections.

Keywords: methicillin-resistant Staphylococcus aureus; penicillenols; synergistic antibacterial activity.

Associated data

figshare/10.6084/m9.figshare.c.4096298