Chitosan-based hydrogels: From preparation to biomedical applications

Michelly C G Pellá; Michele K Lima-Tenório; Ernandes T Tenório-Neto; Marcos R Guilherme; Edvani C Muniz; Adley F Rubira

doi:10.1016/j.carbpol.2018.05.033

Chitosan-based hydrogels: From preparation to biomedical applications

Carbohydr Polym. 2018 Sep 15:196:233-245. doi: 10.1016/j.carbpol.2018.05.033. Epub 2018 May 12.

Authors

Michelly C G Pellá¹, Michele K Lima-Tenório², Ernandes T Tenório-Neto³, Marcos R Guilherme¹, Edvani C Muniz⁴, Adley F Rubira⁵

Affiliations

¹ Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900, Maringá, Paraná, Brazil.
² Department of Chemistry, State University of Ponta Grossa, Av. Gen. Carlos Cavalcanti, 4748, CEP 84030-900, Ponta Grossa, Paraná, Brazil. Electronic address: mk.lima@yahoo.com.
³ Department of Chemistry, State University of Ponta Grossa, Av. Gen. Carlos Cavalcanti, 4748, CEP 84030-900, Ponta Grossa, Paraná, Brazil.
⁴ Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900, Maringá, Paraná, Brazil; Post-graduate Program on Materials Science & Engineering, Federal University of Technology, Paraná (UTFPR-LD), CEP 86036-370, Londrina, Paraná, Brazil.
⁵ Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900, Maringá, Paraná, Brazil. Electronic address: afrubira@gmail.com.

PMID: 29891292
DOI: 10.1016/j.carbpol.2018.05.033

Abstract

The advances in the field of biomaterials have led to several studies on alternative biocompatible devices and to their development focusing on their properties, benefits, limitations, and utilization of alternative resources. Due to their advantages like biocompatibility, biodegradability, and low cost, polysaccharides have been widely used in the development of hydrogels. Among the polysaccharides studied on hydrogels preparation, chitosan (pure or combined with natural/synthetic polymers) have been widely investigated for use in biomedical field. In view of potential applications of chitosan-based hydrogels, this review focuses on the most recent progress made with respect to preparation, properties, and their salient accomplishments for drug delivery and tissue engineering.

Keywords: Biomaterial; Chitosan; Drug delivery; Hydrogel; Tissue engineering.

Publication types

Review