Non-alcoholic fatty liver disease (NAFLD) is one of the most urgent problems of modern medicine - is the subject of numerous studies, causing interest of different medical specialists This paper presents our own experience of supervision of patients with fatty degeneration of liver on the background of the application of human placenta extract - Laennec. We treated 11 patients with fatty degeneration of the liver and examined the motor-evacuation function of the hepa- tobiliary tract before and after treatment. The control group consisted of 50 healthy subject aged between 19 to 21 years. Laennec was administered intramuscularly to 2 ml a day, a course of 20 injections. Usage of placental drug Laennec has a stimulating influence on the processes of choleresis and bile secretion in patients with fatty degeneration of the liver, and normalizes the motility of the sphincter and contractility of the gall bladder.