How can we improve the outcome for transplant patients with nontuberculous mycobacterial infections?

Future Microbiol. 2018 Jun 1:13:903-914. doi: 10.2217/fmb-2018-0006. Epub 2018 Jun 11.

Abstract

Nontuberculous mycobacteria (NTM) are environmental organisms that are rapidly emerging as pathogens in the transplant population. The prevalence of infection in transplant recipients remains unknown. While guidelines exist for treatment of NTM, neither the American Thoracic Society, the Infectious Diseases Society of America, nor the British Thoracic Society guidelines dictate the approach needed for transplant recipients. Here, we summarize risk factors, important diagnostic and treatment facts, and preventive measures to be taken to help improve outcomes of those infected with NTM infections.

Keywords: M. abscessus; M. avium complex; clinical monitoring; drug interactions; hematopoietic cell transplant; mycobacteria; nontuberculous; pretransplant risk; prevention; solid organ transplant.

Publication types

  • Review

MeSH terms

  • Humans
  • Mycobacterium Infections, Nontuberculous / etiology
  • Mycobacterium Infections, Nontuberculous / microbiology*
  • Mycobacterium Infections, Nontuberculous / prevention & control
  • Mycobacterium abscessus / physiology
  • Organ Transplantation / adverse effects*
  • Organ Transplantation / statistics & numerical data
  • Postoperative Complications / etiology
  • Postoperative Complications / microbiology*
  • Postoperative Complications / prevention & control
  • Stem Cell Transplantation / adverse effects*
  • Stem Cell Transplantation / statistics & numerical data
  • Treatment Outcome