Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

Jiangbo Chen; Jiaquan Wang; Tao Tu

doi:10.1002/asia.201800759

Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

Chem Asian J. 2018 Sep 4;13(17):2559-2565. doi: 10.1002/asia.201800759. Epub 2018 Jul 23.

Authors

Jiangbo Chen¹, Jiaquan Wang¹, Tao Tu^{1

2}

Affiliations

¹ Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai, 200438, China.
² State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.

PMID: 29888483
DOI: 10.1002/asia.201800759

Abstract

By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.

Keywords: amino alcohols; hydrogenation; lactams; pincer complexes; ruthenium.

Abstract

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