CD4-HIV-1 Envelope Interactions: Critical Insights for the Simian/HIV/Macaque Model

AIDS Res Hum Retroviruses. 2018 Sep;34(9):778-779. doi: 10.1089/AID.2018.0110. Epub 2018 Jul 9.

Abstract

The macaque models of HIV-1 infection have been a cornerstone of research on transmission, pathogenesis, and prevention. In particular, the infection of macaques with chimeric simian/HIV-1 viruses (SHIVs) is central to the vaccine development pipeline because SHIVs encode the key target of HIV-1-neutralizing antibodies, the HIV-1 envelope (env) protein. In this review, we highlight some of the recent studies that have improved our understanding of the CD4-HIV-1 env interaction, which are crucial for development of SHIV/macaque models of HIV-1 infection.

Keywords: CD4; HIV-1 envelope; SHIV/macaque model.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Neutralizing / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • Disease Models, Animal
  • HIV Infections / immunology*
  • HIV Infections / virology
  • HIV Seropositivity / immunology
  • HIV-1 / immunology*
  • Macaca mulatta / immunology*
  • Macaca mulatta / virology
  • Simian Acquired Immunodeficiency Syndrome / immunology*
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus / immunology*
  • env Gene Products, Human Immunodeficiency Virus / immunology*

Substances

  • Antibodies, Neutralizing
  • env Gene Products, Human Immunodeficiency Virus