Variable role of patent ductus arteriosus

Jennifer Shepherd; Kai-Hsiang Hsu; Shahab Noori

doi:10.1016/j.siny.2018.05.002

Variable role of patent ductus arteriosus

Semin Fetal Neonatal Med. 2018 Aug;23(4):273-277. doi: 10.1016/j.siny.2018.05.002. Epub 2018 Jun 1.

Authors

Jennifer Shepherd¹, Kai-Hsiang Hsu², Shahab Noori³

Affiliations

¹ Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
² Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan.
³ Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: snoori@chla.usc.edu.

PMID: 29884402
DOI: 10.1016/j.siny.2018.05.002

Abstract

Although patent ductus arteriosus is essential in fetal life, interventions to close or minimize the adverse hemodynamic effects associated with the left-to-right shunt are often needed after birth, especially in extremely premature infants. However, there are clinical conditions where maintaining patency of the ductus is essential for survival. In this article we discuss use of prostaglandin E₁ in the management of congenital heart defects, pulmonary hypertension and left ventricular failure in early neonatal period.

Keywords: Congenital diaphragmatic hernia; Congenital heart defect; Patent ductus arteriosus; Prostaglandin; Pulmonary hypertension.

Publication types

Review

MeSH terms

Ductus Arteriosus, Patent / physiopathology*
Heart Defects, Congenital / physiopathology*
Hemodynamics / physiology*
Humans
Infant, Newborn