Two new triterpenoids with antimicrobial activity from the leaves and twigs of Orophea yunnanensis

Nat Prod Res. 2019 Dec;33(24):3472-3477. doi: 10.1080/14786419.2018.1481843. Epub 2018 Jun 8.

Abstract

Two new triterpenoids, 3-O-(4',5'-dihydroxybenzoyl)-lup-20(29)-en (1) and 3-O-(6'-desmethysyringyl)-13α-methyl-27-norolean-14-en-3β-ol (2), were isolated from the leaves and twigs of Orophea yunnanensis. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. Compounds 1 and 2 exhibited the moderate inhibitory activity against Sclerotinia sclerotiorum, Ceratocystis fimbriata and Verticillium dahliae Kleb with MIC values from 50 to 25 μg/mL, and also displayed the weak activity selectively against tested bacteria strains with MIC values from 100 to 50 μg/mL.

Keywords: antibacterial activity; antifungal activity; triterpenoids.

Publication types

  • Video-Audio Media

MeSH terms

  • Annonaceae / chemistry*
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / pharmacology*
  • Ascomycota / drug effects
  • Drug Evaluation, Preclinical
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Spectrometry, Mass, Electrospray Ionization
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology*

Substances

  • Anti-Infective Agents
  • Triterpenes