Dissecting an adiposity locus with an arsenal of genomics

Kim Lorenz; Benjamin F Voight

doi:10.1186/s13059-018-1460-y

Dissecting an adiposity locus with an arsenal of genomics

Genome Biol. 2018 Jun 7;19(1):74. doi: 10.1186/s13059-018-1460-y.

Authors

Kim Lorenz¹, Benjamin F Voight²

Affiliations

¹ Department of Systems Pharmacology and Translational Therapeutics and Department of Genetics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, PA, 19104, USA. kimberly.lorenz@gmail.com.
² Department of Systems Pharmacology and Translational Therapeutics and Department of Genetics, University of Pennsylvania-Perelman School of Medicine, Philadelphia, PA, 19104, USA. bvoight@pennmedicine.upenn.edu.

Abstract

We discuss a recent study that has identified and validated the link between a type-2 diabetes (T2D) association and human adipose biology by means of KLF14 gene expression. In addition to being maternally imprinted, the contributed risk at this locus is greater in female carriers.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Adiposity / genetics*
Animals
Diabetes Mellitus, Type 2 / genetics
Gene Expression
Genetic Loci / genetics*
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study / methods
Genomics / methods
Humans
Sp Transcription Factors / genetics

Substances

Sp Transcription Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding