The First International Conference on Nanotechnology Applications and Implications of Agrochemicals toward Sustainable Agriculture and Food Systems was held in Beijing, China, on November 17-18, 2016 to address and exchange the latest knowledge and developments in nanotechnology of agrochemicals toward sustainable agriculture and food systems. World-leading scientists gathered to discuss a wide range of relevant topics. The purposes of this symposium introduction are to provide an introduction to the international conference, summarize in brief the contributions of papers that follow within this special issue of the Journal of Agricultural and Food Chemistry, provide a synthesis of conference outcomes, and suggest future directions, including an important role of converging science and technologies to advance sustainable agriculture, food, and natural resource systems.