Beware of Undertow: Opioid Drugs Generate Additional Waves of Intracellular Signaling

Dong Wang; Daniel J Berg; Grégory Scherrer

doi:10.1016/j.neuron.2018.05.035

Beware of Undertow: Opioid Drugs Generate Additional Waves of Intracellular Signaling

Neuron. 2018 Jun 6;98(5):870-872. doi: 10.1016/j.neuron.2018.05.035.

Authors

Dong Wang¹, Daniel J Berg¹, Grégory Scherrer²

Affiliations

¹ Department of Anesthesiology, Perioperative and Pain Medicine, Department of Neurosurgery, Department of Molecular and Cellular Physiology, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA.
² Department of Anesthesiology, Perioperative and Pain Medicine, Department of Neurosurgery, Department of Molecular and Cellular Physiology, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA; New York Stem Cell Foundation - Robertson Investigator, Stanford University, Palo Alto, CA 94304, USA. Electronic address: gs25@stanford.edu.

Abstract

In this issue of Neuron, Stoeber et al. (2018) report a biosensor resolving the spatiotemporal organization of opioid receptor activation in living neurons. They delineate novel signaling mechanisms in endosomes and Golgi differentially engaged by opioid peptides and drugs.

Publication types

Comment

MeSH terms

Analgesics, Opioid*
Biosensing Techniques*
Neurons
Signal Transduction / drug effects

Substances

Analgesics, Opioid

Abstract

Publication types

MeSH terms

Substances

Grants and funding