Influence without Presence: PRDM16 Casts Destiny

Qing-Ran Bai; Qin Shen

doi:10.1016/j.neuron.2018.05.030

Influence without Presence: PRDM16 Casts Destiny

Neuron. 2018 Jun 6;98(5):867-869. doi: 10.1016/j.neuron.2018.05.030.

Authors

Qing-Ran Bai¹, Qin Shen²

Affiliations

¹ Tongji Hospital, Brain and Spinal Cord Innovative Research Center, School of Life Sciences and Technology, Tongji University, Shanghai 200065, China; PTN Graduate Program, School of Life Sciences, Tsinghua University, Beijing 100084, China.
² Tongji Hospital, Brain and Spinal Cord Innovative Research Center, School of Life Sciences and Technology, Tongji University, Shanghai 200065, China. Electronic address: shenqin@tongji.edu.cn.

PMID: 29879386
DOI: 10.1016/j.neuron.2018.05.030

Abstract

Chromatin modifications play an important role in cortical neurogenesis. In this issue, Baizabal et al. (2018) show how PRDM16, a histone methyltransferase, influences upper layer neuron production and migration by pre-setting enhancer activity within the developmental radial glial lineage.

Publication types

Comment

MeSH terms

Ependymoglial Cells*
Epigenesis, Genetic
Neurogenesis
Neurons
Transcription Factors / genetics*

Substances

Transcription Factors