Abstract
A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Basidiomycota / chemistry
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Cell Line, Tumor
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Cytotoxins / chemistry
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Cytotoxins / pharmacology*
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Drug Screening Assays, Antitumor / methods
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Fungi / chemistry
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Humans
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PC-3 Cells
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Polycyclic Sesquiterpenes
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Polyporaceae / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology*
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Terpenes / chemistry
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Terpenes / pharmacology*
Substances
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Antineoplastic Agents
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Cytotoxins
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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Terpenes
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drimane