The Effect of Plasmodium on the Outcome of Ebola Virus Infection in a Mouse Model

Kyle Rosenke; Reinaldo Mercado-Hernandez; Jacqueline Cronin; Solomon Conteh; Patrick Duffy; Heinz Feldmann; Emmie de Wit

doi:10.1093/infdis/jiy236

The Effect of Plasmodium on the Outcome of Ebola Virus Infection in a Mouse Model

J Infect Dis. 2018 Nov 22;218(suppl_5):S434-S437. doi: 10.1093/infdis/jiy236.

Authors

Kyle Rosenke¹, Reinaldo Mercado-Hernandez¹, Jacqueline Cronin¹, Solomon Conteh², Patrick Duffy², Heinz Feldmann¹, Emmie de Wit¹

Affiliations

¹ Laboratory of Virology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, Montana.
² Laboratory of Malaria Immunology and Vaccinology, NIAID, NIH Bethesda, Maryland.

Abstract

Following the Ebola virus epidemic in West Africa, several studies investigated whether there was an effect of Plasmodium coinfection on survival in Ebola virus (EBOV) disease patients. Different effects of coinfection were found in different patient cohorts. To determine whether an effect of Plasmodium coinfection on EBOV survival may exist, we modeled coinfection of Plasmodium yoelii and mouse-adapted EBOV (MA-EBOV) in CD1 mice. Subsequent infection with MA-EBOV at different time points after P. yoelii infection did not have any significant effect on survival.

Publication types

Research Support, N.I.H., Intramural

MeSH terms

Animals
Coinfection / mortality*
Disease Models, Animal
Hemorrhagic Fever, Ebola / mortality*
Humans
Malaria / mortality*
Mice
Plasmodium yoelii*