A multi-channel optical fiber refractometer based on S fiber taper (SFT) cascaded with fiber Bragg grating (FBG) is proposed and experimentally demonstrated. The compact SFT acts as an in-line Mach-Zehnder interferometer (MZI) to be used as a band-pass filter (BPF) to tailor the FBG reflection, whose transmission spectrum is sensitive to the surrounding refractive index (SRI). Thus, the peak power of the FBG reflection is modulated by the SRI. The three-channel SRI monitor can be achieved by discriminating the different center wavelength and peak power variation of the FBG reflections. Experimental results show that the RI sensitivities of Channels 1, 2, and 3 are 345.54, 349.57, and 463.60 dB/RIU, respectively. Moreover, the temperature cross-sensitivity can be solved by interrogating the center wavelength of the FBG reflection.