Abstract
Nivolumab is an anti-programmed cell death-1 (PD-1) antibody that is utilized as an immune checkpoint inhibitor (ICI) for cancer therapy. We herein present the case of a 57-year-old man who developed acute kidney injury during treatment with nivolumab for lung cancer. A renal biopsy revealed acute tubulointerstitial nephritis. Immunohistochemical staining demonstrated marked infiltration of macrophages and T cells together with mild B cell infiltration. Of note, strong CD163+ M2 macrophage infiltration was observed. The cessation of nivolumab and high-dose prednisolone therapy improved the renal function of the patient. Further, we review the pertinent literature on renal-infiltrating cells in ICI-induced tubulointerstitial nephritis.
Keywords:
M2 macrophage; acute tubulointerstitial nephritis; anti-PD-1 antibody; immune checkpoint inhibitor.
MeSH terms
-
Acute Kidney Injury / chemically induced
-
Acute Kidney Injury / drug therapy
-
Acute Kidney Injury / immunology
-
Acute Kidney Injury / pathology
-
Antibodies / immunology*
-
Antigens, CD / immunology
-
Antigens, Differentiation, Myelomonocytic / immunology
-
Antineoplastic Agents, Immunological / adverse effects*
-
Antineoplastic Agents, Immunological / immunology*
-
B-Lymphocytes / immunology
-
B-Lymphocytes / pathology
-
B7-H1 Antigen / antagonists & inhibitors
-
B7-H1 Antigen / immunology
-
Humans
-
Immunologic Factors / therapeutic use
-
Kidney / immunology
-
Kidney / pathology*
-
Lung Neoplasms / drug therapy
-
Macrophages / immunology
-
Macrophages / pathology
-
Male
-
Middle Aged
-
Nephritis, Interstitial / chemically induced*
-
Nephritis, Interstitial / drug therapy
-
Nephritis, Interstitial / immunology
-
Nephritis, Interstitial / pathology*
-
Nivolumab / adverse effects*
-
Nivolumab / immunology*
-
Prednisolone / therapeutic use
-
Programmed Cell Death 1 Receptor
-
Receptors, Cell Surface / immunology
-
T-Lymphocytes / immunology
-
T-Lymphocytes / pathology
Substances
-
Antibodies
-
Antigens, CD
-
Antigens, Differentiation, Myelomonocytic
-
Antineoplastic Agents, Immunological
-
B7-H1 Antigen
-
CD163 antigen
-
CD274 protein, human
-
Immunologic Factors
-
Programmed Cell Death 1 Receptor
-
Receptors, Cell Surface
-
Nivolumab
-
Prednisolone
Supplementary concepts
-
Acute Tubulointerstitial Nephritis