Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

Bodhisattwa Mondal; Hongxia Chen; Weihua Wen; Ercole L Cavalieri; Eleanor G Rogan; Muhammad Zahid

doi:10.1021/acsomega.7b01727

Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

ACS Omega. 2018 May 31;3(5):5511-5515. doi: 10.1021/acsomega.7b01727. Epub 2018 May 21.

Authors

Bodhisattwa Mondal¹, Hongxia Chen¹, Weihua Wen¹, Ercole L Cavalieri¹, Eleanor G Rogan¹, Muhammad Zahid¹

Affiliation

¹ Department of Environmental, Agricultural, and Occupational Health, College of Public Health, and the Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Abstract

Arsenic trioxide (As₂O₃) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As₂O₃-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As₂O₃-induced cytotoxicity. As₂O₃, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As₂O₃ caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of As₂O₃ on enzymes involved in estrogen metabolism.