Small RNA data set that includes tRNA-derived fragments from Jurkat cells treated with camptothecin

Mehmet Ilyas Cosacak; Ipek Erdogan; Ayten Nalbant; Bunyamin Akgul

doi:10.1016/j.dib.2018.01.050

Small RNA data set that includes tRNA-derived fragments from Jurkat cells treated with camptothecin

Data Brief. 2018 Feb 3:17:397-400. doi: 10.1016/j.dib.2018.01.050. eCollection 2018 Apr.

Authors

Mehmet Ilyas Cosacak^{1

2}, Ipek Erdogan¹, Ayten Nalbant¹, Bunyamin Akgul¹

Affiliations

¹ Izmir Institute of Technology, Department of Molecular Biology and Genetics, Gulbahcekoyu, Urla, 35430 Izmir, Turkey.
² German Center for Neurodegenerative Diseases Dresden, DFG-Center for Regerenative Therapies Dresden, Cluster of Excellence, TU Dresden FetscherstraBe 105, 01307 Dresden, Germany.

Abstract

In this article, we report a small RNA data set obtained from human T cell acute leukemia Jurkat cells, which were treated with the universal apoptotic agent camptothecin. Based on the Annexin-V labeling pattern, we sorted two Jurkat subpopulations in treated cells: one that is sensitive to the drug and the other being relatively more resistant. We report new original data that include the frequency of tRNA-derived fragments (tRF) in drug-sensitive and resistant cells. We also present partially analyzed data to show the origin of reads on tRNAs as well as the borders of the fragments. We believe that this data can benefit the science community working in the field of tRF and/or apoptosis.