Data on differentially expressed miRNAs in dogs infected with Leishmania infantum

Jaqueline Poleto Bragato; Larissa Martins Melo; Gabriela Lovizutto Venturin; Gabriela Torres Rebech; Leandro Encarnação Garcia; Flavia Lombardi Lopes; Valéria Marçal Felix de Lima

doi:10.1016/j.dib.2018.01.007

Data on differentially expressed miRNAs in dogs infected with Leishmania infantum

Data Brief. 2018 Jan 9:17:218-225. doi: 10.1016/j.dib.2018.01.007. eCollection 2018 Apr.

Authors

Jaqueline Poleto Bragato¹, Larissa Martins Melo¹, Gabriela Lovizutto Venturin¹, Gabriela Torres Rebech¹, Leandro Encarnação Garcia², Flavia Lombardi Lopes², Valéria Marçal Felix de Lima¹

Affiliations

¹ Department of Animal Clinic, Surgery and Reproduction, São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil.
² Department of Support, Production and Animal Health, São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil.

Abstract

This paper contains data on differentially expressed miRNAs in peripheral blood mononuclear cells (PBMC) of dogs naturally infected by Leishmania (L.) infantum compared to healthy dogs. In recent years, studies with miRNAs have shown that these molecules play a critical role in the regulation and function of immune response.Differentially expressed miRNAs were identified by microarray, validated by real time PCR and compared with parasite load in the dogs. Targets and pathways were analyzed using the Ingenuity Pathway Analysis program.

Keywords: Dog; Leishmania infantum; miRNA.