Phenytoin Augmentation of Levetiracetam Treatment: A Case of Forced Normalization With Emergence of Psychosis

Cureus. 2018 Apr 5;10(4):e2432. doi: 10.7759/cureus.2432.

Abstract

Forced normalization is the emergence of psychoses following stabilization of seizures in an uncontrolled epileptic patient. The current study is a case of forced normalization, a phenomenon characterized by normalization of electroencephalogram (EEG) findings and resolution of seizures. This case report is unique and rare because the patient meets the diagnostic merit of forced normalization, which occurred due to a nonconventional method of seizure control management. We discuss the recognition and differential diagnoses of such cases, understanding the phenomenon of forced normalization and treatment strategies, which may help clinicians in their clinical practice.

Keywords: anticonvulsant; antiepileptic (aed)-induced psychotic disorder (aipd); epilepsy seizures; forced normalization; kindling; levetiracetam; phenytoin; psychoses; seizure control convulsions.; seizure disorder.

Publication types

  • Case Reports