Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete Amycolatopsisalbispora WP1T

Mar Drugs. 2018 Jun 7;16(6):199. doi: 10.3390/md16060199.

Abstract

Marine actinobacteria continue to be a rich source for the discovery of structurally diverse secondary metabolites. Here we present a new hydroxymate siderophore produced by Amycolatopsis albispora, a recently described species of this less explored actinomycete genus. Strain WP1T was isolated from sediments collected at -2945 m in the Indian Ocean. The new siderophore, designated albisporachelin, was isolated from iron depleted culture broths and the structure was established by 1D and 2D NMR and MS/MS experiments, and application of a modified Marfey's method. Albisporachelin is composed of one N-methylated-formylated/hydroxylated l-ornithine (N-Me-fh-l-Orn), one l-serine (l-Ser), one formylated/hydroxylated l-ornithine (fh-l-Orn) and a cyclo-N-methylated-hydroxylated l-ornithine (cyclo-N-Me-h-l-Orn).

Keywords: Amycolatopsis; deep ocean sediment; siderophore.

MeSH terms

  • Actinomycetales / chemistry*
  • Geologic Sediments / chemistry*
  • Geologic Sediments / microbiology*
  • Hydroxamic Acids / chemistry*
  • Indian Ocean
  • Iron / chemistry
  • Lipids / chemistry*
  • Ornithine / analogs & derivatives*
  • Ornithine / chemistry
  • Seawater / microbiology*
  • Siderophores / chemistry*

Substances

  • Hydroxamic Acids
  • Lipids
  • Siderophores
  • ornithine containing aminolipid
  • Iron
  • Ornithine