Abstract
Extracellular polysaccharides (EPS) could increase the penetration of fluoride through dental biofilm, reducing its cariogenicity. We measured the concentration of fluoride in EPS-containing (EPS+) or not-containing (EPS-) Streptococcus mutans bacterial pellets resembling test biofilms, before and up to 60 min after a 0.05% NaF rinse in situ. Fluoride penetration and clearance were higher in EPS+ bacterial pellets. The data suggest that EPS enhances fluoride penetration, but also accelerates fluoride clearance from dental biofilms.
Keywords:
Biofilms; Diet; Diffusion; Fluoride; Plaque fluid; Sucrose.
© 2018 S. Karger AG, Basel.
Publication types
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Biofilms / drug effects*
-
Cariostatic Agents / chemistry*
-
Cariostatic Agents / pharmacology
-
Cross-Over Studies
-
Dental Caries / microbiology
-
Diffusion
-
Double-Blind Method
-
Fluorides / chemistry*
-
Fluorides / pharmacology
-
Fructose / chemistry
-
Glucose / chemistry
-
Humans
-
Osmolar Concentration
-
Polysaccharides, Bacterial / chemistry*
-
Regression Analysis
-
Saliva / physiology
-
Statistics, Nonparametric
-
Streptococcus mutans / drug effects*
-
Streptococcus mutans / physiology
-
Sucrose / chemistry
Substances
-
Cariostatic Agents
-
Polysaccharides, Bacterial
-
Fructose
-
Sucrose
-
Glucose
-
Fluorides