Is maintenance treatment in adult acne important? Benefits from maintenance therapy with adapalene, and low doses of alpha and beta hydroxy acids

J Dermatolog Treat. 2019 Sep;30(6):568-571. doi: 10.1080/09546634.2018.1484874. Epub 2019 Apr 11.

Abstract

Background: Adult acne is a chronic disease with uncontrolled exacerbations, associated with a psychological burden of the patient and medical expenses. Aims: The aim of the study was to check the efficacy of maintenance therapy of adult acne. It is essential part of treatment as adult acne usually has a long-lasting and recurring course. Methods: In the study, the efficacy of maintenance therapy in patients with adult acne is evaluated. In this study, 100 patients (aged 25-39 years of age) with mild and moderate adult acne were enrolled. Results: The maintenance therapy (adapalene 0.1% three times a week and low doses of alpha and beta hydroxy acids) led to a significant decrease in the number of acne lesions (from 31.3 to 12.25; p < .001) and severity of seborrhea (p < .001). Conclusions: Maintenance therapy brings significant improvements in the reduction of non-inflammatory and inflammatory lesions in patients with mild and moderate adult acne.

Keywords: Adult acne; alpha and beta hydroxy acids; maintenance therapy; retinoids.

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / pathology
  • Adapalene / therapeutic use*
  • Adult
  • Chronic Disease
  • Dermatologic Agents / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Gels / chemistry
  • Humans
  • Hydroxy Acids / therapeutic use*
  • Male
  • Recurrence
  • Severity of Illness Index
  • Treatment Outcome

Substances

  • Dermatologic Agents
  • Gels
  • Hydroxy Acids
  • Adapalene

Supplementary concepts

  • Acne, Adult