Breast cancer is the number two leading cause of death in women all over the world and is often associated with poor quality of life (QOL). The positive and negative QOL factors influence the overall health and well-being of those affected with invasive ductal carcinoma (IDC). This literature review was structured to identify and understand both the positive and negative QOL factors throughout breast cancer treatment, as well as post breast cancer treatment. Systemic searches were done of three databases to gather data in breast cancer treatment from 2010-2015. Results identified the positive and negative factors associated with the QOL in relation to breast cancer treatment. The most prevalent positive QOL factors included patient expectations, decreased side effects, and increased survival rate. The most prevalent negative QOL factors included treatment, specific side effects and decreased quality of life. This review may guide healthcare professionals in incorporating new practices and identifying the best regimen to improving QOL. The positive and negative QOL factors, in relation to treatment, are important because they help healthcare professionals understand how those factors impact the overall health and well-being of individuals with IDC.