Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Leli Zeng; Gongcheng Ma; Jing Lin; Peng Huang

doi:10.1002/smll.201800782

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Small. 2018 Jul;14(30):e1800782. doi: 10.1002/smll.201800782. Epub 2018 Jun 5.

Authors

Leli Zeng¹, Gongcheng Ma¹, Jing Lin¹, Peng Huang¹

Affiliation

¹ Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.

PMID: 29873182
DOI: 10.1002/smll.201800782

Abstract

Photoacoustic (PA) imaging (PAI) is a noninvasive and nonionizing biomedical imaging modality that combines the advantages of optical imaging and ultrasound imaging. Based on PAI, photoacoustic detection (PAD) is an emerging approach that is involved with the interaction between PA probes and analytes resulting in the changes of photoacoustic signals for molecular detection with rich contrast, high resolution, and deep tissue penetration. This Review focuses on the recent development of PA probes in PAD. The following contents will be discussed in detail: 1) the construction of PA probes; 2) the applications and mechanisms of PAD to different types of analytes, including microenvironments, small biomolecules, or metal ions; 3) the challenges and perspectives of PA probes in PAD.

Keywords: molecule detection; photoacoustic detection; photoacoustic imaging; photoacoustic probes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biosensing Techniques
Ions
Metals / chemistry
Molecular Imaging / methods*
Molecular Imaging / trends*
Molecular Probes / chemistry*
Photoacoustic Techniques / methods*
Photoacoustic Techniques / trends*

Substances

Ions
Metals
Molecular Probes