Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats

Hayato Ikeda; Yoshihiko Hayashi; Naruto Takahashi; Tadashi Watabe; Yasukazu Kanai; Atsushi Shinohara; Hiroki Kato; Hiroshi Watabe; Eku Shimosegawa; Jun Hatazawa

doi:10.1016/j.apradiso.2018.05.021

Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats

Appl Radiat Isot. 2018 Sep:139:251-255. doi: 10.1016/j.apradiso.2018.05.021. Epub 2018 May 23.

Authors

Affiliations

¹ Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
² Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan.
³ Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
⁴ Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
⁵ Cyclotron and Radioisotope Center, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
⁶ Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan; Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, 565-0871 Osaka, Japan. Electronic address: hatazawa@tracer.med.osaka-u.ac.jp.

PMID: 29870920
DOI: 10.1016/j.apradiso.2018.05.021

Abstract

We proposed use of astatine-210 in preclinical study. Astatine-210 has higher yield of production and is easier to quantify than astatine-211. We produced astatine-210 with Bi target and 40 MeV alpha beam accelerated by cyclotron, free astatine-210 was separated and injected to normal rats. Three male rats (blocking group) were injected non-radioactive iodide before injection of astatine-210. Compared with the control group, the astatine-210 accumulations in the blocking group decreased to 24% in the thyroid.

Keywords: Accelerator; Accumulations of astatine; Astatine-210; Iodide blocking; Thyroid gland.

MeSH terms

Alpha Particles / adverse effects
Alpha Particles / therapeutic use
Animals
Astatine / administration & dosage*
Astatine / isolation & purification
Astatine / pharmacokinetics*
Male
Radiation Protection
Rats
Rats, Wistar
Sodium Iodide / administration & dosage*
Thyroid Gland / metabolism
Thyroid Gland / radiation effects
Tissue Distribution

Substances

Astatine-210
Sodium Iodide
Astatine