The circadian clock is a cell autonomous oscillator that controls many aspects of physiology through generating rhythmic gene expression in a time of day dependent manner. In addition, in endothermic mammals body temperature cycles contribute to rhythmic gene expression. These body temperature-controlled rhythms are hard to distinguish from classic circadian rhythms if analyzed in vivo in endothermic organisms. However, they do not fulfill all criteria of being circadian if analyzed in cell culture or in conditions where body temperature of an endothermic organism can be manipulated. Here we review and compare these characteristics, discuss the core clock independent mechanism of temperature-controlled alternative splicing and highlight the requirement of double-checking rhythms that appear circadian within an endothermic organism in a system that allows temperature manipulation.
Keywords: alternative splicing; body temperature; circadian clock; endothermic; temperature-controlled gene expression.
© 2018 WILEY Periodicals, Inc.