Characterization of a NIR absorbing thienyl curcumin contrast agent for photoacoustic imaging

Chem Commun (Camb). 2018 Jun 14;54(49):6352-6355. doi: 10.1039/c8cc03727b.

Abstract

The synthesis and characterization of a bis(2-dimethylaminothien-5-yl)curcumin boron difluoride chromophore is presented. Photophysical, electrochemical and computational investigations establish the properties of its absorption in the Vis-NIR spectral range relative to established curcumin dyes. Application of this thienyl curcumin dye as a photoacoustic contrast agent is investigated against the dicarbocyanine Cy5 dye in the 675-735 nm excitation range.