An Examination of the Multi-Faceted Motivation System in Healthy Young Adults

Susana Da Silva; Areti Apatsidou; Sarah Saperia; Ishraq Siddiqui; Eliyas Jeffay; Aristotle N Voineskos; Zafiris J Daskalakis; Gary Remington; Konstantine K Zakzanis; George Foussias

doi:10.3389/fpsyt.2018.00191

An Examination of the Multi-Faceted Motivation System in Healthy Young Adults

Front Psychiatry. 2018 May 11:9:191. doi: 10.3389/fpsyt.2018.00191. eCollection 2018.

Authors

Susana Da Silva^{1

2}, Areti Apatsidou³, Sarah Saperia¹, Ishraq Siddiqui^{1

2}, Eliyas Jeffay³, Aristotle N Voineskos^{1

2

4}, Zafiris J Daskalakis^{1

2

4}, Gary Remington^{1

2

4}, Konstantine K Zakzanis³, George Foussias^{1

2

4}

Affiliations

¹ Centre for Addiction and Mental Health, Toronto, ON, Canada.
² Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
³ Department of Psychology, University of Toronto Scarborough, Scarborough, ON, Canada.
⁴ Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Abstract

Background: Amotivation is a prevalent symptom in schizophrenia (SZ) and depression (MDD), and is linked to poor functional outcomes in affected individuals. Conceptualizations of motivation have outlined a multi-faceted construct comprised of reward responsiveness, reward expectancy, reward valuation, effort valuation, and action selection/preference-based decision making. To date, findings from studies utilizing variable-centered approaches to examining isolated facets of motivation in SZ and MDD have been inconsistent. Thus, the present study adopted a person-centered approach, and comprehensively examined the reward system in a non-clinical sample in an attempt to explore potential subtypes of motivation impairments, while minimizing the effects of illness-related confounds. Methods: Ninety-six healthy undergraduate students were evaluated for amotivation, schizotypal traits, depressive symptoms, and cognition, and administered objective computerized tasks to measure the different facets of motivation. Cluster analysis was performed to explore subgroups of individuals based on similar motivation task performance. Additionally, correlational analyses were conducted in order to examine inter-relationships between motivation facets, and relations between clinical measures and facets of motivation. Results: Cluster analysis identified two subgroups of individuals with differential motivation performance profiles. Correlational analyses revealed that reward responsiveness was associated with amotivation, depressive symptoms, and negative schizotypy. Further, significant inter-correlations were found between reward responsiveness and reward expectancy, as well as between reward valuation and effort valuation. Conclusions: Our results mark important steps forward in understanding motivation in a non-clinical sample, and guide future dimensional and comprehensive analyses of the multi-faceted reward system. It remains to be seen whether these patterns of results will be similar in clinical populations such as SZ and MDD.

Keywords: RDoC; amotivation; depressive symptoms; reward system; schizotypal traits.