Primary endometrial squamous cell carcinoma is an extremely rare tumor that tends to occur in postmenopausal women. We report on a 33-year-old woman who presented with a history of irregular vaginal bleeding for more than 2 years, and a vaginal mass for more than 1 month. Biopsy of the vaginal mass revealed an invasive poorly differentiated squamous cell carcinoma. The patient underwent radical hysterectomy, bilateral salpingo-oophorectomy, omentectomy, pelvic lymph node dissection, peritoneal sampling and vaginal tumor resection. On the basis of her medical history, auxiliary examination and postoperative pathology, the patient was diagnosed with stage IV endometrial squamous cell carcinoma. The patient was followed-up regularly and remained in good condition.
Keywords: Primary endometrial squamous cell carcinoma; endometrial carcinoma; endometrium; human papillomavirus; p53; reproductive age.