Abstract
We report the case of a patient treated by ipilimumab and nivolumab for a metastatic melanoma. After a mild clinical thyroiditis and a transient biological hyperthyroidism she rapidly demonstrated a peripheral hypothyroidism with appearance of antibodies against thyroperoxidase and thyroglobulin.
Keywords:
hypothyroidism; ipilimumab; melanoma; nivolumab; thyroiditis.
MeSH terms
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Adult
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / adverse effects*
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Autoantibodies / blood
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Autoantigens / immunology
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Disease Progression
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Female
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Humans
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Hypothyroidism / blood
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Hypothyroidism / chemically induced*
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Hypothyroidism / diagnosis
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Immunotherapy / adverse effects*
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Iodide Peroxidase / immunology
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Ipilimumab / administration & dosage
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Ipilimumab / adverse effects*
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Iron-Binding Proteins / immunology
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Melanoma / blood
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Melanoma / drug therapy*
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Nivolumab
Substances
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Antibodies, Monoclonal
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Autoantibodies
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Autoantigens
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Ipilimumab
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Iron-Binding Proteins
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anti-thyroglobulin
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Nivolumab
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TPO protein, human
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Iodide Peroxidase