Immunotherapy-induced hypothyroidism A report of melanoma treated by ipilimumab and nivolumab

Ann Biol Clin (Paris). 2018 Jun 1;76(3):326-328. doi: 10.1684/abc.2018.1350.

Abstract

We report the case of a patient treated by ipilimumab and nivolumab for a metastatic melanoma. After a mild clinical thyroiditis and a transient biological hyperthyroidism she rapidly demonstrated a peripheral hypothyroidism with appearance of antibodies against thyroperoxidase and thyroglobulin.

Keywords: hypothyroidism; ipilimumab; melanoma; nivolumab; thyroiditis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / adverse effects*
  • Autoantibodies / blood
  • Autoantigens / immunology
  • Disease Progression
  • Female
  • Humans
  • Hypothyroidism / blood
  • Hypothyroidism / chemically induced*
  • Hypothyroidism / diagnosis
  • Immunotherapy / adverse effects*
  • Iodide Peroxidase / immunology
  • Ipilimumab / administration & dosage
  • Ipilimumab / adverse effects*
  • Iron-Binding Proteins / immunology
  • Melanoma / blood
  • Melanoma / drug therapy*
  • Nivolumab

Substances

  • Antibodies, Monoclonal
  • Autoantibodies
  • Autoantigens
  • Ipilimumab
  • Iron-Binding Proteins
  • anti-thyroglobulin
  • Nivolumab
  • TPO protein, human
  • Iodide Peroxidase