Nanoinformatics Revolutionizes Personalized Cancer Therapy

Tamar Sadan; David P Cormode; Rachela Popovtzer

doi:10.1016/j.trecan.2018.04.002

Nanoinformatics Revolutionizes Personalized Cancer Therapy

Trends Cancer. 2018 Jun;4(6):397-399. doi: 10.1016/j.trecan.2018.04.002. Epub 2018 Apr 25.

Authors

Tamar Sadan¹, David P Cormode², Rachela Popovtzer³

Affiliations

¹ Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel.
² Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
³ Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel. Electronic address: rachela.popovtzer@biu.ac.il.

PMID: 29860981
DOI: 10.1016/j.trecan.2018.04.002

Abstract

Designing personalized cancer nanomedicines is a challenging process. The emerging field of nanoinformatics can facilitate this process by enabling computational design of nanocarrier-encapsulated drugs. Recent data show that quantitative structure-nanoparticle assembly calculations predict particle formation and size, and can lead to safer and more effective personalized cancer therapeutics.

Keywords: caveolin-mediated endocytosis; machine learning; nanoinformatics; nanomedicine; tyrosine kinase inhibitors.

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MeSH terms

Humans
Nanomedicine*
Nanoparticles
Neoplasms*