Isolation and sequence analysis of a novel rhesus macaque foamy virus isolate with a serotype-1-like env

Arch Virol. 2018 Sep;163(9):2507-2512. doi: 10.1007/s00705-018-3892-9. Epub 2018 Jun 2.

Abstract

SFVmmu-DPZ9524 represents the third completely sequenced rhesus macaque simian foamy virus (SFV) isolate, alongside SFVmmu_K3T with a similar SFV-1-type env, and R289HybAGM with a SFV-2-like env. Sequence analysis demonstrates that, in gag and pol, SFVmmu-DPZ9524 is more closely related to R289HybAGM than to SFVmmu_K3T, which, outside of env, is more similar to a Japanese macaque isolate than to the other two rhesus macaque isolates SFVmmu-DPZ9524 and R289HybAGM. Further, we identify bel as another recombinant locus in R289HybAGM, confirming that recombination contributes to sequence diversity in SFV.

MeSH terms

  • Animals
  • DNA, Viral / genetics*
  • Gene Expression
  • Gene Products, env / genetics
  • Gene Products, gag / genetics
  • Gene Products, pol / genetics
  • Macaca mulatta / virology*
  • Monkey Diseases / virology*
  • Phylogeny
  • Recombination, Genetic*
  • Retroviridae Infections / veterinary*
  • Retroviridae Infections / virology
  • Sequence Analysis, DNA
  • Serogroup
  • Simian foamy virus / classification
  • Simian foamy virus / genetics*
  • Simian foamy virus / isolation & purification

Substances

  • DNA, Viral
  • Gene Products, env
  • Gene Products, gag
  • Gene Products, pol