Tubulin Posttranslational Modifications and Emerging Links to Human Disease

Maria M Magiera; Puja Singh; Sudarshan Gadadhar; Carsten Janke

doi:10.1016/j.cell.2018.05.018

Tubulin Posttranslational Modifications and Emerging Links to Human Disease

Cell. 2018 May 31;173(6):1323-1327. doi: 10.1016/j.cell.2018.05.018. Epub 2018 May 31.

Authors

Maria M Magiera¹, Puja Singh², Sudarshan Gadadhar², Carsten Janke³

Affiliations

¹ Institut Curie, PSL Research University, CNRS UMR3348, Orsay, France; Université Paris Sud, Université Paris-Saclay, CNRS UMR3348, Orsay, France. Electronic address: maria.magiera@curie.fr.
² Institut Curie, PSL Research University, CNRS UMR3348, Orsay, France; Université Paris Sud, Université Paris-Saclay, CNRS UMR3348, Orsay, France.
³ Institut Curie, PSL Research University, CNRS UMR3348, Orsay, France; Université Paris Sud, Université Paris-Saclay, CNRS UMR3348, Orsay, France. Electronic address: carsten.janke@curie.fr.

PMID: 29856952
DOI: 10.1016/j.cell.2018.05.018

Abstract

Tubulin posttranslational modifications are currently emerging as important regulators of the microtubule cytoskeleton and thus have a strong potential to be implicated in a number of disorders. Here, we review the latest advances in understanding the physiological roles of tubulin modifications and their links to a variety of pathologies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Blood Platelets / metabolism
Cilia / metabolism
Cytoskeleton / metabolism
Flagella / metabolism
Heart Diseases / metabolism
Humans
Mice
Microtubules / metabolism
Mutation
Neurodegenerative Diseases / therapy
Phenotype
Protein Processing, Post-Translational*
Risk Factors
Tubulin / chemistry*
Tubulin / physiology

Substances

Tubulin