Urea derivative has been used to catalyze the asymmetric aldol reaction of isatins with ketones. The resulting 3-alkyl-3-hydroxy-indolin-2-ones products were obtained in good yields (70%-94%) with high enantioselectivities (up to 87%ee).
Keywords: 3-alkyl-3-hydroxy-indolin-2-ones; enantioselective aldol reaction; isatins; urea derivative.
© 2018 Wiley Periodicals, Inc.